Metformin-attenuated sepsis-induced oxidative damages: a novel role for metformin

Metformin protects primary rat hepatocytes against oxidative stress-induced apoptosis

The majority of chronic liver diseases are accompanied by oxidative stress, which induces apoptosis in hepatocytes and liver injury. Recent studies suggest that oxidative stress and insulin resistance are important in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and the pathophysiology of diabetes complications. Metformin has been shown to be hepatoprotective in the insulin-resi...

Metformin induced acute pancreatitis

Acute pancreatitis frequently presents with abdomen pain but may presents with various skin manifestations as rash and rarely, pancreatic panniculitis. Metformin, one of the most effective and valuable oral hypoglycemic agents in the biguanide class was linked to acute pancreatitis in few cases. Here, we report a case of metformin induce acute pancreatitis in young healthy man with normal renal...

Metformin-Induced Hemolytic Anemia

OBJECTIVE To report a rare side effect of metformin, an oral antidiabetic drug that is used for the treatment of type 2 diabetes mellitus. CLINICAL PRESENTATION AND INTERVENTION A 17-year-old boy was hospitalized for receiving acute lymphoblastic leukemia treatment that was composed of vincristine, L-asparaginase, daunorubicin, and prednisone. Hyperglycemia was determined without any clinical...

Metformin-induced paroxysmal dystonia.

Metformin-Induced Hepatotoxicity

Metformin is the first choice oral antidiabetic drug for type 2 diabetes and currently the most consumed.Althoughgastrointestinal intolerance is frequent, metformin-induced hepatotoxicity is rare. Fewer than 10 cases have been reported (1). In all of those cases, metformin was associated with concomitant intake of other potentially hepatotoxic drugs. We present what we feel may be the first doc...

future of metformin administration in sepsis management

sepsis as the host responsive syndrome is one of the main concerning issues and costly disease on intensive care unit (icu) in the 21st century. epidemiological studies have showed that mortality rates of sepsis in icu and hospitals among 37 countries were 39.2% and 49.6% respectively [1].  complicated nature of sepsis is still not well understood and this makes it hard to treat and manage. acc...